Yogulitsa Yogulitsa Natural Atractylodes Lancea Mafuta a Daily Chemical Viwanda Herb Extract Atractylis Mafuta

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ZOYENERA KUGWIRITSA NTCHITO NDIPONSO ZOFUNIKA KUDZIWA: Izi zikutanthawuza kuwonjezera, osati m'malo mwa upangiri wochokera kwa dokotala kapena wothandizira zaumoyo ndipo sizikutanthauza kuti zigwiritse ntchito zonse zomwe zingatheke, kusamala, kuyanjana kapena zotsatirapo zoipa. Izi mwina sizingafanane ndi thanzi lanu. Osachedwetsa kapena kunyalanyazidwa kufunafuna upangiri wamankhwala kuchokera kwa adokotala kapena othandizira ena oyenerera chifukwa cha zomwe mwawerenga pa WebMD. Muyenera kulankhula ndi dokotala wanu nthawi zonse musanayambe, kuyimitsa, kapena kusintha gawo lililonse la ndondomeko ya chithandizo chamankhwala kapena chithandizo ndi kudziwa kuti ndi chithandizo chanji chomwe chili choyenera kwa inu.

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Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zolemba Zamalonda

pisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) ndi khansa yofala pakati pa amuna ndi akazi, makamaka ku Thailand. Kafukufuku waposachedwa adawonetsa kuti kutulutsa kwa ethanol kwa AL kunapangitsa kuti pakhale njira yoletsa kutsata kwa OV-induced CCA nyama popanda poizoni wowonekera kudzera pakamwa kwa masiku 30 malinga ndi zotsatira za positron emission tomography-computed tomography ndi hamster zachimuna zaku Syria [7]. Pofuna kufufuza zotsatira za AL rhizome pakuyenda kwa m'mimba, mbewa za atropine-, dopamine-, ndi 5-hydroxytryptamine (5-HT) zinatengedwa mu phunziroli. Zotsatira zake zidawonetsa kuti chotsitsa cha 1 mg/kg chikhoza kupondereza kutulutsa kwa m'mimba komwe kumachitika chifukwa cha dopamine komanso kuchepa kwa m'mimba kudzera mu jakisoni wa intraperitoneal. Kutulutsa kwa 1000 mg / kg kumatha kulepheretsa kuchepa kwamatumbo a atropine, ndipo kutulutsa kwa 500 mg / kg kumatha kulepheretsa kutuluka kwa m'mimba kwa 5-HT komanso kuchepa kwamatumbo ang'onoang'ono.8]. Kuphatikiza apo, AL idagwiritsa ntchito zotsutsana ndi zilonda zam'mimba mumtundu wa makoswe kudzera pakuchepetsa zolumikizira zotupa (mwachitsanzo, tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), ndi prostaglandin E2 (PGE2) ndi kuwonjezeka kwa epidermal growth factor (EGF) ndi trefoil factor2 (TFF2) [9]. Tizilombo toyambitsa matenda a mafangasi otengedwa munthaka timachepetsa 30% zokolola za mtedza [10]. Posachedwapa, zidanenedwa kuti kubzala mtedza ndi mtedza, AL kungathenso kupondereza matenda oyamba ndi fungus omwe amafalitsidwa ndi dothi poletsaFusarium oxysporumkukula [11]. Kutulutsa kwa petroleum ether (PE) kuchokera ku AL kunawonetsa zoletsa pa BGC-823 ndi SGC-7901 maselo a khansa ya m'mimba yamunthu. Gawo la PE lingapangitse apoptosis, kumangidwa kwa cell cycle, ndi kusintha kwa mitochondrial transmembrane [12]. Lipoti laposachedwa linanena kuti MeOH yochokera ku AL ikhoza kuletsa nitric oxide (NO) kupanga mu lipopolysaccharide-stimulated murine macrophage-monga RAW264.7 maselo ndi kuyambitsa granulocyte-colony stimulating factor (G-CSF) secretion mu murine normal colonic epithelial MCE301 maselo. NO ndi free radical [13]. Kutulutsa kwa ethanol kwa AL kunapangitsa kuti lipase ikhale yofunika kwambiri pa lipase ndi IC50 9.06 µg/mL mu pancreatic lipase assay ya munthu, ndipo idawonetsa zotsatira zotsutsana ndi kunenepa kwambiri pazakudya zamafuta ambiri zomwe zimapangitsa mbewa kunenepa kwambiri pamlingo wokwera wa 500 mg. /kg [14]. Zotulutsa zamadzi zochokera ku AL zikuwonetsa zochita zotsutsana ndi serotonin zolandilira komanso zoletsa pakusankha kwa 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane-induced mutu-twitch response mu mbewa. [15]. Madzi amadzi kuchokera ku AL amachepetsa kawopsedwe ka triptolide kudzera pakuwongolera kwachiwindi kwa CYP3A. Pakalipano, AL ikhoza kusintha zotsatira zotsutsana ndi kutupa za triptolide. Zotsatirazi zikuwonetsa kuti AL ikhoza kuletsa kawopsedwe ndikuwonjezera achire a triptolide kudzera kuphatikiza.