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Yogulitsa Yogulitsa Natural Atractylodes Lancea Mafuta a Daily Chemical Viwanda Herb Extract Atractylis Mafuta
ZOYENERA KUGWIRITSA NTCHITO NDIPONSO ZOFUNIKA KUDZIWA: Izi zikutanthawuza kuwonjezera, osati m'malo mwa upangiri wochokera kwa dokotala kapena wothandizira zaumoyo ndipo sizikutanthauza kuti zigwiritse ntchito zonse zomwe zingatheke, kusamala, kuyanjana kapena zotsatirapo zoipa. Izi mwina sizingafanane ndi thanzi lanu. Osachedwetsa kapena kunyalanyazidwa kufunafuna upangiri wamankhwala kuchokera kwa adokotala kapena othandizira ena oyenerera chifukwa cha zomwe mwawerenga pa WebMD. Muyenera kulankhula ndi dokotala wanu nthawi zonse musanayambe, kuyimitsa, kapena kusintha gawo lililonse la ndondomeko ya chithandizo chamankhwala kapena chithandizo ndi kudziwa kuti ndi chithandizo chanji chomwe chili choyenera kwa inu.
Zinthu zomwe zili ndi copyright zimaperekedwa ndi Natural Medicines Comprehensive Database Consumer Version. Chidziwitso chochokera ku gwero ili ndi umboni komanso cholinga, komanso popanda chikoka chamalonda. Kuti mudziwe zambiri zachipatala zamankhwala achilengedwe, onani Natural Medicines Comprehensive Database Professional Version.
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Yogulitsa Yogulitsa Natural Atractylodes Lancea Mafuta a Daily Chemical Viwanda Herb Extract Atractylis Mafuta
Kodi muzu wa Atractylodes lancea ndi chiyani?
Atractylodes lancea ndi chomera chaku China, chomera chamtengo wapatali, chomwe chimalimidwa chifukwa cha ma rhizomes ake. Ma rhizomes ake ali ndi mafuta ofunikira.
Kugwiritsa Ntchito & Ubwino:
Lili ndi anti-inflammatory properties, limachepetsa khungu likagwiritsidwa ntchito. Zitha kukhala zothandiza kwa ziphuphu zakumaso, khungu lokwiya.
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Mafuta a Menthol CamphorBorneol Pakusamba Ndi Aromatherapy
Ubwino Wathanzi Ndi Ntchito
Borneol imapereka njira yopindulitsa kwambiri yamankhwala aku Western ndi Eastern. Zotsatira za Borneol ndizofala pochiza matenda osiyanasiyana. Mu Chinese Medicine, zimagwirizanitsidwa ndi chiwindi, ndulu meridians, mtima, ndi mapapo. M'munsimu muli mndandanda wa zina mwa ubwino wake wathanzi.
Amalimbana ndi matenda a kupuma komanso matenda a m'mapapo
Kafukufuku wambiri akuwonetsa kuti terpenes, ndi Borneol, makamaka, amachepetsa matenda opuma. Borneol ndikusonyeza mphamvumu kuchepetsa kutupa kwa mapapu mwa kuchepetsa kutupa kwa cytokines ndi kulowetsedwa kotupa. Anthu omwe amagwiritsa ntchito Chinese Medicine amagwiritsanso ntchito Borneol pochiza matenda a bronchitis ndi matenda ofanana.
Anticancer properties
Borneol yawonetsansoanticancer propertiespowonjezera zochita za Selenocysteine (SeC). Izi zachepetsa kufalikira kwa khansa kudzera mu apoptotic (programmed) cell cell kufa. M'maphunziro ambiri, Borneol yawonetsanso kuchuluka kwa magwiridwe antchitokulunjika kwa mankhwala a antitumor.
Ogwira analgesic
Mu akuphunzirapoganizira kupweteka kwapambuyo kwa anthu, ntchito yapamwamba ya Borneol inachititsa kuchepetsa kupweteka kwambiri poyerekeza ndi gulu lolamulira la placebo. Kuphatikiza apo, ma acupuncturists amakonda kugwiritsa ntchito Borneol pamutu chifukwa chamankhwala ake ochepetsa ululu.
Anti-yotupa kanthu
Borneol ndianasonyezakutsekereza njira zina za ion zomwe zimalimbikitsa kupweteka komanso kutupa. Zimathandizanso kuchepetsa ululu ku matenda otupa monganyamakazi.
Zotsatira za Neuroprotective
Borneol imapereka chitetezo china kukufa kwa ma neuronal cellpakakhala ischemic stroke. Zimathandiziranso kusinthika kwa minofu yaubongo ndikukonzanso. Amaganiziridwa kuti akhale ndi zotsatira za neuroprotective posintha ma permeability amagazi-ubongo chotchinga.
Amalimbana ndi nkhawa komanso kutopa
Ena omwe amagwiritsa ntchito mitundu ya cannabis yokhala ndi milingo yayikulu ya Borneol akuwonetsa kuti amachepetsa kupsinjika kwawo ndikuchepetsa kutopa, motero, amalola kukhala omasuka popanda kukhazikika. Anthu omwe amagwiritsa ntchito Chinese Medicine nawonso amavomerezamphamvu zake zochepetsera nkhawal.
Entourage zotsatira
Monga ndi ma terpenes ena, zotsatira za Borneol kuphatikiza ndi cannabinoids za cannabis zawonetsa.kulimbikitsa zotsatira.Izi zimachitika pamene mankhwalawo amagwirira ntchito limodzi kuti apereke chithandizo chowonjezereka chamankhwala. Borneol imatha kukulitsa kutsekeka kwa chotchinga chamagazi muubongo, ndikupangitsa kuti mamolekyu achire azidutsa mosavuta kupita ku dongosolo lapakati lamanjenje.
Kupatula pamankhwala ambiri a Borneol, amagwiritsidwanso ntchito kwambiri pothamangitsa tizilombo chifukwa chakupha kwake kwachilengedwe ku nsikidzi zambiri. Mafuta onunkhira amasokonezanso Borneol chifukwa cha fungo lake lokoma kwa anthu.
Zowopsa Zomwe Zingatheke ndi Zotsatira zake
Borneol nthawi zambiri imadziwika kuti terpene yachiwiri mu cannabis, kutanthauza kuti imawoneka mocheperako. Mlingo wocheperako wa Borneol umaganiziridwa kuti ndi wotetezeka. Komabe, pamilingo yayikulu yakutali kapena kuwonekera kwa nthawi yayitali, Borneol imatha kukhala ndi zinazoopsa zomwe zingatheke ndi zotsatira zake, kuphatikizapo:
- Kukwiya pakhungu
- Kukwiya kwa mphuno ndi mmero
- Mutu
- Mseru ndi kusanza
- Chizungulire
- Kuwala mutu
- Kukomoka
Ndi kuwonekera kwambiri kwa Borneol, anthu amatha kukumana ndi izi:
- Kusakhazikika
- Kusokonezeka
- Kusatchera khutu
- Kukomoka
- Akamezedwa, amatha kukhala poizoni kwambiri
Ndikofunikira kudziwa kuti kuchuluka komwe kuli mu cannabis sikungathe kuyambitsa izi. Kukwiyitsanso sikuchitika ndi Mlingo wocheperako womwe umagwiritsidwa ntchito pochepetsa ululu ndi zotsatira zina.
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Mafuta Oyera a Cnidii Fructus amakandulo ndi sopo kupanga mafuta ophatikizira mafuta ofunikira atsopano pazowotchera bango
Cnidium ndi chomera chomwe chimachokera ku China. Zapezekanso ku US ku Oregon. Zipatso, mbewu, ndi ziwalo zina za mbewu zimagwiritsidwa ntchito ngati mankhwala.
Cnidium yakhala ikugwiritsidwa ntchito mu Traditional Chinese Medicine (TCM) kwa zaka masauzande ambiri, nthawi zambiri pakhungu. N'zosadabwitsa kuti cnidium ndi chinthu chodziwika bwino mu mafuta odzola a ku China, mafuta odzola, ndi mafuta odzola.
Anthu amatenga cnidium pakamwa kuti achulukitse kugonana ndi chilakolako chogonana, komanso kuchiza erectile dysfunction (ED). Cnidium imagwiritsidwanso ntchito pazovuta kukhala ndi ana (kusabereka), kumanga thupi, khansa, mafupa ofooka (osteoporosis), ndi matenda a fungal ndi mabakiteriya. Anthu ena amatenganso kuti awonjezere mphamvu.
Cnidium imagwiritsidwa ntchito pakhungu chifukwa cha kuyabwa, totupa, chikanga, ndi zipere.
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Mafuta onunkhira amafuta onunkhira onunkhira onunkhira a makandulo ndi sopo opanga mafuta ophatikizira mafuta ofunikira atsopano opangira mabango.
Chemical zikuchokera ATR
Mapangidwe a mankhwala a ATR makamaka ndi zigawo zosasunthika komanso zosasunthika. Mafuta ofunikira a ATR (ATEO) amawerengedwa kuti ndi gawo logwira ntchito la ATR, ndipo zomwe zili mu ATEO ndizomwe zimawonetsa kutsimikiza kwa zomwe zili mu ATR. Pakalipano, pali kafukufuku wosiyanasiyana pazigawo zosasunthika komanso kafukufuku wocheperako pazigawo zosasinthika. Zigawo zosasunthika zimakhala zovuta kwambiri, ndipo mitundu yayikulu yamagulu ndi phenylpropanoids (phenylpropanoids yosavuta, lignans ndi coumarins) ndi terpenoids (monoterpenes, sesquiterpenes, diterpenoids ndi triterpenes). Zigawo zosasunthika zimakhala makamaka alkaloids, aldehydes ndi zidulo, quinones ndi ketoni, sterols, amino acid, ndi chakudya. Zotsatira za kafukufuku wa ATR chemical composition zidzathandiza pa chitukuko cha kafukufuku wake wabwino.
Zosasinthasintha
Ofufuzawo adagwiritsa ntchito njira zoyesera zowunikira monga chromatography ndi GC-MS kusanthula zigawo zamankhwala za ATR kuchokera kochokera kosiyanasiyana, magulu osiyanasiyana, njira zosiyanasiyana zochotsera ndi magawo osiyanasiyana. Kafukufuku wam'mbuyomu adawonetsa kuti zigawo zazikulu za mankhwala mu ATR zinali mafuta osasinthika, omwe ndi chizindikiro chofunikira pakuwunika kwa ATR. α-Asarone ndi β-asarone ndi 95% ya mafuta osasinthika a ATR ndipo adadziwika kuti ndi zigawo zikuluzikulu (Chithunzi 1) (Lam et al., 2016a). "Pharmacopoeia of The People's Republic of China" (Kusindikiza kwa 2020) imalemba kuti mafuta osakhazikika a ATR sayenera kuchepera 1.0% (mL/g). Pakadali pano, mitundu ingapo yamafuta osasunthika idapezeka mu ATR
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Mafuta onunkhira amafuta onunkhira onunkhira onunkhira a makandulo ndi sopo opanga mafuta ophatikizira mafuta ofunikira atsopano opangira mabango.
Perilla ndi zitsamba. Tsamba ndi mbewu zimagwiritsidwa ntchito popanga mankhwala.
Perilla amagwiritsidwa ntchito pochiza mphumu. Amagwiritsidwanso ntchito ngati nseru, kutentha kwa dzuwa, kutulutsa thukuta, komanso kuchepetsa kugunda kwa minofu.
Muzakudya, perilla imagwiritsidwa ntchito ngati chokometsera.
Popanga, mafuta a perilla amagwiritsidwa ntchito popanga ma vanishi, utoto, ndi inki.
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Mafuta onunkhira amafuta onunkhira onunkhira onunkhira a makandulo ndi sopo opanga mafuta ophatikizira mafuta ofunikira atsopano opangira mabango.
Angelica ndi chomera. Muzu, mbewu, ndi zipatso zimagwiritsidwa ntchito kupanga mankhwala.
Angelica amagwiritsidwa ntchito pa kutentha kwa pamtima, mpweya wa m'mimba (kutuluka m'mimba), kusowa kwa njala (anorexia), nyamakazi, vuto la kuyendayenda, "mphuno yopuma" (kupuma kwa catarrh), mantha, mliri, ndi vuto la kugona (kusowa tulo).
Amayi ena amagwiritsa ntchito angelica kuti ayambe kusamba. Nthawi zina izi zimachitika kuti achotse mimba.
Angelica amagwiritsidwanso ntchito kuonjezera kupanga mkodzo, kukonza chilakolako chogonana, kulimbikitsa kupanga ndi kutulutsa phlegm, ndi kupha majeremusi.
Anthu ena amapaka angelica mwachindunji pakhungu chifukwa cha ululu wa mitsempha (neuralgia), kupweteka kwa mafupa (rheumatism), ndi matenda a khungu.
Kuphatikiza ndi zitsamba zina, Angelica amagwiritsidwanso ntchito pochiza umuna msanga.
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100% Mafuta Ofunika Kwambiri A Zitsamba a Cyperus Opanga Sopo Opanga Mafuta a Cyperus Rotundus
Nutgrass ndi therere lodziwika bwino lomwe limagwiritsidwa ntchito popanga ma skincare ambiri. Malinga ndi Ayurveda, yakhala ikugwiritsidwa ntchito m'magulu osiyanasiyana omwe adakonzedwa kuti achepetse mawanga amdima ndi zina.
Ubwino…
Zapezekanso m'mankhwala ambiri a Ayurvedic pochiza zotupa, matenda oyamba ndi fungus komanso zikhalidwe zapakhungu. Mafuta a Nutgrass muzu ndi amphamvu kwambiri ndipo ali ndi antioxidants, omwe amathandiza kuchepetsa ukalamba wa khungu chifukwa amagwira ntchito kuchepetsa mizere yabwino ndi makwinya. Zimathandizira kuwongolera kuchuluka kwa pigment, melanin, pakhungu. Potero amabwezeretsa kuwala kwa khungu. Nutgrass ndi yozizira mwachilengedwe, katundu wake wotsutsa-kutupa amathandiza kuchepetsa kufiira, kuphulika, ndi khungu lotupa. Zatsimikiziridwa pochiza matenda aakulu a khungu. Lili ndi mafuta acids, mavitamini ndi flavonoids omwe ali opindulitsa kwambiri pakhungu komanso tsitsi. Zinthuzi zimawonjezera kuwala kwa khungu, ndikulimbitsa tsitsi ndi kuwala ndi voliyumu.
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Mafuta apamwamba achilengedwe a Notopterygium omwe amagwiritsidwa ntchito pa Zaumoyo
Pankhani yochotsa mphepo ndikuchotsa chinyontho, pali zitsamba zambiri zaku China. Chifukwa chake, kuyerekeza notopterygium ndi anzawo omwe ali ndi machiritso ofanana kungatithandize kumvetsetsa chomera chamankhwala ichi bwino.
Muzu wa notopterygium ndi Angelica Root (Du Huo) imatha kuyeretsa mpweya ndikuwonjezera ululu ndi kuuma kwa mafupa. Koma ali ndi mphamvu zawozawo ndi zofooka zawo motsatana. Yoyamba imakhala ndi chilengedwe champhamvu komanso kukoma, zomwe zimapangitsa kuti ikhale ndi antipyretic effect kudzera mu thukuta komanso kukwera mphamvu. Pachifukwa ichi, ndi zitsamba zabwino kwambiri za matenda a msana ndi ululu kumtunda ndi kumbuyo kwa mutu. Poyerekeza, muzu wa angelica uli ndi mphamvu yotsika, yomwe imapangitsa kuti ikhale ndi mphamvu yochiritsa bwino pa rheumatism ya m'munsi mwa thupi ndi kupweteka kwa phazi, kumbuyo, mwendo, ndi shin. Chifukwa chake, nthawi zambiri amagwiritsidwa ntchito ngati mankhwala awiriawiri chifukwa ndi othandizira kwambiri.
Onse notopterygium ndiGui Zhi (Ramulus Cinnamomi)ndi bwino kutulutsa mphepo ndi kuchotsa kuzizira. Koma wakaleyo amakonda kunyowa kwa mphepo kumutu, khosi, ndi kumbuyoGui ZhiNdi bwino kuthana ndi mphepo-yonyowa pa mapewa, mikono, ndi zala.
Bothe notopterygium ndiFang Feng (Radix Saposhnikoviae)ndi apadera pakutulutsa mphepo. Koma choyambirira chimakhala ndi mphamvu kuposa Fang Feng.
Masiku ano pharmacological zochita za notopterygium mizu
1. Jakisoni wake ali ndi analgesic ndi antipyretic zotsatira. Komanso, ali chopinga pa bowa khungu ndi brucellosis;
2. Gawo lake losungunuka lili ndi zoyeserera zotsutsana ndi arrhythmic;
3. Mafuta ake osasunthika amakhalanso ndi anti-inflammatory, analgesic ndi antipyretic zotsatira. Ndipo imatha kukana motsutsana ndi pituitrin-induced myocardial ischemia ndikuwonjezera kuthamanga kwa magazi kwa myocardial;
4. Mafuta ake osasinthasintha amalepheretsabe kuchedwa kwa mtundu wa hypersensitivity mu mbewa.Zitsanzo za maphikidwe a notopterygium incisum pamankhwala azitsamba
Zhong Guo Yao Dian (Chinese pharmacopoeia) amakhulupirira kuti ndi acrid ndi owawa mu kukoma ndi kutentha mu chilengedwe. Zimakwirira ma meridians a chikhodzodzo ndi impso. Ntchito zazikuluzikulu ndikutulutsa mphepo, kuchotsa kuzizira, kuchotsa chinyontho, ndi kuthetsa ululu. Zomwe zimagwiritsidwa ntchito ndi notopterygium ndizophatikizamutumu mtundu wozizira-mphepochimfine, rheumatism, ndi kupweteka kwa phewa ndi msana. Mlingo wovomerezeka ndi 3 mpaka 9 magalamu.
1. Qiang HuoFu ZiTang from Yi Xue Xin Wu (Medical Revelations). Zimaphatikizidwa ndi Fu Zi (Aconite),Gan Jiang(Ginger WoumaRoot), ndi ZhiGan Cao(Honey Fried Licorice Root) kuchiza ubongo wogwidwa ndi tizilombo tozizira tachilendo, kuwawa kwa muubongo komwe kumatuluka m'mano, miyendo yozizira, komanso mpweya woziziritsa wochokera mkamwa ndi mphuno.
2. Jiu Wei Qiang Huo Tang kuchokeraCi ShiNan Zhi (Chidziwitso Chovuta Kwambiri). Amapangidwa ndi Fang Feng, Xi Xin (Herba Asari),Chuan Xiong(lovage root), ndi zina zotero kuchiza matenda akunja oziziritsa ndi mphepo limodzi ndi chinyontho, kuzizira, kutentha thupi, kusatuluka thukuta, mutu,khosi lolimba, ndi kupweteka kwa mafupa akuthwa m’miyendo.
3. Qiang Huo Sheng Shi Tang kuchokera ku Nei Wai Shang Bian Huo Lun (Kufotokozera Zokayikitsa Zokhudza Kuvulala Kuchokera Zomwe Zimayambitsa Mkati ndi Zakunja). Amagwiritsidwa ntchito limodzi ndi mizu ya angelica,Gao Ben(Rhizoma Ligustici), Fang Feng, ndi zina zotero kuti achiritse kunja-kunyowa kwamphepo, kupweteka kwa mutu komanso kuuma kowawa kwa msana, kupweteka kwam'munsi kumbuyo, komanso kupweteka kwam'malo molumikizana ndi thupi lonse.
4. Juan Bi Tang, yemwe amadziwikanso kuti notopterygium nditurmerickuphatikiza, kuchokera ku Bai Yi Xuan Fang (Malangizo Osankhidwa Molondola). Imagwira ntchito ndi Fang Feng, Jiang Huang (Curcuma Longa),Dang Gui(Dong Quai), etc. kuthetsa mphepo-kuzizira-dampness arthralgia kumtunda kwa thupi, kupweteka pamodzi mapewa ndi miyendo.
5. Qiang Huo Gong Gao Tang wochokera ku Shen Shi Yao Han (Buku Lofunika Kwambiri laOphthalmology). Imalumikizana ndi mizu ya lovage,Bayi Zhi(Angelica Dahurica), Rhizoma Ligustici, ndi zina zotero.
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Mafuta oyera a Aucklandia lappa a makandulo ndi sopo opangira mafuta ophatikizira mafuta ofunikira atsopano opangira bango.
Osteoarthritis (OA) ndi amodzi mwa matenda omwe nthawi zambiri amasokonekera m'mafupa omwe amakhudza anthu azaka zopitilira 65.1]. Nthawi zambiri, odwala OA amapezeka kuti ali ndi cartilage yowonongeka, synovium yotentha, ndi ma chondrocytes owonongeka, zomwe zimayambitsa ululu ndi kupsinjika maganizo [2]. Kupweteka kwa nyamakazi kumayamba makamaka chifukwa cha kuwonongeka kwa chichereŵechereŵe m’malo olumikizirana mafupa chifukwa cha kutupa, ndipo chichereŵechereŵenga chikawonongeka kwambiri mafupa amatha kuwombana wina ndi mnzake kumayambitsa kupweteka kosaneneka komanso kuvutikira thupi [3]. Kuphatikizidwa kwa oyimira pakati otupa omwe ali ndi zizindikiro monga kupweteka, kutupa, ndi kuuma kwa mgwirizano kumalembedwa bwino. Odwala OA, ma cytokines otupa, omwe amachititsa kukokoloka kwa cartilage ndi subchondral bone amapezeka mu synovial fluid.4]. Madandaulo akulu awiri omwe odwala OA amakhala nawo nthawi zambiri ndi ululu ndi kutupa kwa synovial. Chifukwa chake zolinga zazikulu zamankhwala amakono a OA ndikuchepetsa ululu ndi kutupa. [5]. Ngakhale mankhwala omwe alipo, kuphatikizapo mankhwala osagwiritsa ntchito steroidal ndi steroidal, atsimikizira kuti amachepetsa ululu ndi kutupa, kugwiritsa ntchito mankhwalawa kwa nthawi yaitali kumakhala ndi zotsatira zoopsa pa thanzi monga mtima, m'mimba, ndi aimpso [6]. Choncho, mankhwala othandiza kwambiri okhala ndi zotsatira zochepa ayenera kupangidwa pofuna kuchiza nyamakazi ya osteoarthritis.Zaumoyo zachilengedwe zikuchulukirachulukira kuti ndizotetezeka komanso zopezeka mosavuta [7]. Mankhwala achikhalidwe aku Korea atsimikizira kuti ali ndi mphamvu zolimbana ndi matenda angapo otupa, kuphatikiza nyamakazi [8]. Aucklandia lappa DC. amadziwika chifukwa cha mankhwala, monga kupititsa patsogolo kayendedwe ka qi pofuna kuthetsa ululu ndi kuchepetsa m'mimba, ndipo wakhala akugwiritsidwa ntchito ngati mankhwala achilengedwe [9]. Malipoti am'mbuyomu akuwonetsa kuti A. lappa ali ndi anti-inflammatory [10,11], ochepetsa ululu [12], anticancer [13] ndi gastroprotective [14] zotsatira. Zochita zosiyanasiyana zamoyo za A. lappa zimayambitsidwa ndi mankhwala ake akuluakulu: costunolide, dehydrocostus lactone, dihydrocostunolide, costuslactone, α-costol, saussurea lactone ndi costuslactone [15]. Kafukufuku wam'mbuyomu amati costunolide inawonetsa anti-inflammatory properties mu lipopolysaccharide (LPS), yomwe inachititsa macrophages kupyolera mu kayendetsedwe ka NF-kB ndi njira ya mapuloteni a kutentha.16,17]. Komabe, palibe kafukufuku yemwe wafufuza ntchito zomwe A. lappa angachite pochiza OA. Kafukufuku wapano wafufuza za chithandizo cha A. lappa motsutsana ndi OA pogwiritsa ntchito (monosodium-iodoacetate) MIA ndi mitundu ya makoswe a acetic acid.Monosodium-iodoacetate (MIA) imagwiritsidwa ntchito kwambiri popanga zowawa zambiri komanso mawonekedwe a pathophysiological a OA mu nyama.18,19,20]. Pamene jekeseni m'magulu a mawondo, MIA imasokoneza kagayidwe kake ka chondrocyte ndipo imayambitsa kutupa ndi zizindikiro zotupa, monga cartilage ndi subchondral bone erosion, zizindikiro zazikulu za OA [18]. Kuyankha kwamphamvu komwe kumapangidwa ndi acetic acid kumawonedwa mofala ngati kuyerekezera kwa ululu wam'mphepete mwa nyama komwe ululu wotupa ukhoza kuyeza mochulukira [19]. Mzere wa cell wa mbewa wa macrophage, RAW264.7, umagwiritsidwa ntchito kwambiri pophunzira mayankho amtundu wa kutupa. Pambuyo poyambitsa ndi LPS, macrophages a RAW264 amachititsa njira zotupa ndipo amatulutsa oyimira angapo otupa, monga TNF-α, COX-2, IL-1β, iNOS, ndi IL-6 [20]. Kafukufukuyu adawunikira zotsatira za anti-nociceptive ndi anti-inflammatory za A. lappa motsutsana ndi OA mu MIA chitsanzo cha nyama, chitsanzo cha acetic acid-induced animal model, ndi LPS-activated RAW264.7 maselo.2. Zida ndi Njira
2.1. Zomera Zomera
Muzu wouma wa A. lappa DC. zomwe zidagwiritsidwa ntchito pakuyesa zidagulidwa ku Epulip Pharmaceutical Co., Ltd., (Seoul, Korea). Zinadziwika ndi Prof. Donghun Lee, Dept. of Herbal pharmacology, Col. of Korean Medicine, Gachon University, ndipo nambala ya voucher inayikidwa ngati 18060301.2.2. HPLC Analysis of A. lappa Extract
A. lappa adatengedwa pogwiritsa ntchito chipangizo cha reflux (madzi osungunuka, 3 h pa 100 °C). Njira yochotsera idasefedwa ndikufupikitsidwa pogwiritsa ntchito evaporator yotsika mphamvu. Chotsitsa cha A. lappa chinali ndi zokolola za 44.69% pambuyo poumitsa-kuzizira pansi pa −80 °C. Kusanthula kwa Chromatographic kwa A. lappa kunachitika ndi HPLC yolumikizidwa pogwiritsa ntchito 1260 InfinityⅡ HPLC-system (Agilent, Pal Alto, CA, USA). Pakupatukana kwa chromatic, EclipseXDB C18 column (4.6 × 250 mm, 5 µm, Agilent) idagwiritsidwa ntchito pa 35 °C. Okwana 100 mg wa chitsanzo anali kuchepetsedwa mu 10 mL wa 50% methanol ndi sonicated 10 min. Zitsanzo zidasefedwa ndi sefa ya syringe (Waters Corp., Milford, MA, USA) ya 0.45 μm. Mapangidwe a gawo la mafoni anali 0.1% phosphoric acid (A) ndi acetonitrile (B) ndipo gawoli linatulutsidwa motere: 0-60 min, 0%; 60-65 min, 100%; 65-67 min, 100%; 67-72 min, 0% zosungunulira B ndi kuthamanga kwa 1.0 mL / min. Madzi otayira amawonedwa pa 210 nm pogwiritsa ntchito jekeseni wa 10 μL. Kusanthula kunachitika katatu.2.3. Nyumba ndi Kasamalidwe ka Zinyama
Makoswe aamuna a Sprague-Dawley (SD) azaka za masabata a 5 ndi mbewa zamphongo za ICR zazaka za 6 zidagulidwa kuchokera ku Samtako Bio Korea (Gyeonggi-do, Korea). Zinyama zinkasungidwa m'chipinda pogwiritsa ntchito kutentha kosasintha (22 ± 2 ° C) ndi chinyezi (55 ± 10%) ndi kuwala / mdima wa 12/12 h. Nyamazo zinkadziwika bwino ndi vutoli kwa nthawi yoposa sabata imodzi isanayambe kuyesa. Nyama zinali ndi ad libitum kupereka chakudya ndi madzi. Malamulo amakono osamalira ndi kusamalira nyama ku Yunivesite ya Gachon (GIACUC-R2019003) adatsatiridwa mosamalitsa pamachitidwe onse oyesera nyama. Phunzirolo linapangidwa kuti likhale loyesa-khungu komanso lofanana. Tinatsatira njira ya euthanasia molingana ndi malangizo a Komiti Yoyeserera Yanyama.2.4. Jekeseni wa MIA ndi Chithandizo
Makoswe adagawidwa mwachisawawa m'magulu anayi, omwe ndi sham, control, indomethacin, ndi A. lappa. Pokhala ndi anesthetized ndi 2% isofluorane O2 osakaniza, makoswe anabayidwa pogwiritsa ntchito 50 μL ya MIA (40 mg / m; Sigma-Aldrich, St. Louis, MO, USA) intra-articularly m'magulu a mawondo kuti atsogolere ku OA yoyesera. Mankhwalawa adachitidwa monga pansipa: magulu olamulira ndi achinyengo adasungidwa kokha ndi zakudya zoyambira za AIN-93G. Pokhapokha, gulu la indomethacin linapatsidwa indomethacin (3 mg/kg) yophatikizidwa muzakudya za AIN-93G ndipo gulu la A. lappa 300 mg/kg linapatsidwa chakudya cha AIN-93G chowonjezera ndi A. lappa (300 mg/kg). Mankhwalawa adapitilizidwa kwa masiku 24 kuyambira tsiku la kulowetsedwa kwa OA pamlingo wa 15-17 g pa 190-210 g kulemera kwa thupi tsiku lililonse.2.5. Kuyeza Kulemera kwake
Pambuyo pa kulowetsedwa kwa OA, kuyeza kulemera kwa miyendo yakumbuyo kwa makoswe kunachitidwa ndi incapacitance-MeterTester600 (IITC Life Science, Woodland Hills, CA, USA) monga momwe anakonzera. Kugawa kulemera pamiyendo yakumbuyo kunawerengedwa: kunyamula kulemera (%) -
Chinese Angelica Dahurica Muzu Wotulutsa Mafuta Otikita minofu
Kugwiritsa ntchito Angelica
Kugwiritsa ntchito zowonjezera kuyenera kuchitidwa payekha ndikuyesedwa ndi katswiri wazachipatala, monga katswiri wazakudya, wamankhwala, kapena wopereka chithandizo chamankhwala. Palibe chowonjezera chomwe chimapangidwira kuchiza, kuchiza, kapena kupewa matenda.
Umboni wamphamvu wa sayansi wotsimikizira kugwiritsa ntchito Angelica ulibe. Mpaka pano, kafukufuku wambiri paAngelica archangelicazakhala zikuchitika pazitsanzo za nyama kapena m'ma laboratories. Pazonse, mayesero ambiri aumunthu amafunikira pa mapindu omwe Angelica angakhale nawo.
Zotsatirazi ndikuwona zomwe kafukufuku omwe alipo kale akunena pakugwiritsa ntchito Angelica.
Nocturia
NocturiaNdi vuto lomwe limafotokozedwa ngati kufunika kodzuka kutulo kamodzi kapena zingapo usiku uliwonse kuti akodze. Angelica adaphunziridwa kuti agwiritsidwe ntchito pochiza nocturia.
Mu kafukufuku wina wakhungu wachiwiri, omwe anali ndi nocturia omwe adapatsidwa amuna pakubadwa adasinthidwa kuti alandireplacebo(chinthu chosagwira ntchito) kapena chopangidwa kuchokera kuAngelica archangelicamasamba kwa masabata asanu ndi atatu.4
Ophunzirawo adafunsidwa kuti azitsatira mu diaries pamene iwokukodza. Ofufuzawo adawunika zolembazo nthawi yamankhwala isanayambe komanso itatha. Pamapeto pa phunziroli, omwe adatenga Angelica adanenanso za kuchepa kwa usiku (kufunika kudzuka pakati pausiku kuti akodze) kusiyana ndi omwe adatenga placebo, koma kusiyana kwake sikunali kwakukulu.4
Tsoka ilo, maphunziro ena ochepa apangidwa kuti adziwe ngati Angelica amatha kusintha kwambiri nocturia. Kafukufuku wambiri akufunika m'derali.
Khansa
Ngakhale palibe chowonjezera kapena therere chomwe chingathe kuchizakhansa, pali chidwi ndi Angelica ngati chithandizo chothandizira.
Ofufuza adaphunzira momwe Angelica amatha kuletsa khansa mu labu. Mu kafukufuku wina wotere, ofufuza adayesaAngelica archangelicakuchotsa pakhansa ya m'maweremaselo. Adapeza kuti Angelica atha kuthandizira kufa kwa maselo a khansa ya m'mawere, zomwe zidapangitsa ofufuza kunena kuti zitsamba zitha kukhala nazoantitumorkuthekera.5
Kafukufuku wakale kwambiri wochitidwa pa mbewa anapeza zotsatira zofanana.6 Komabe, zotsatirazi sizinabwerezedwe m'mayesero aumunthu. Popanda mayesero aumunthu, palibe umboni wakuti Angelica angathandize kupha maselo a khansa yaumunthu.
Nkhawa
Angelica wakhala akugwiritsidwa ntchito mu mankhwala achikhalidwe monga chithandizo chamankhwalankhawa. Komabe, umboni wasayansi wotsimikizira zimenezi ndi wosoŵa.
Monga momwe zimagwiritsidwira ntchito zina za Angelica, kafukufuku wokhudzana ndi kugwiritsidwa ntchito kwake mu nkhawa nthawi zambiri amachitidwa mu labu kapena pazitsanzo za nyama.
Mu kafukufuku wina, zolemba za Angelica zinaperekedwa kwa makoswe asanachitenkhawamayeso. Malinga ndi ochita kafukufuku, makoswe anachita bwino atalandira Angelica, zomwe zimapangitsa kuti zikhale chithandizo cha nkhawa.7
Mayesero aumunthu ndi kafukufuku wowonjezereka amafunika kuti adziwe zomwe Angelica angathe kuchita pochiza nkhawa.
Antimicrobial Properties
Angelica amanenedwa kuti ali ndi mankhwala oletsa tizilombo toyambitsa matenda, koma maphunziro opangidwa bwino a anthu sanachitidwe kuti atsimikizire izi.
Malinga ndi ofufuza ena, Angelica amawonetsa antimicrobial zochita motsutsana ndi:2
- Clostridium difficile (C. zosiyana)
- Clostridium perfringens
- Enterococcus faecalis
- Eubacterium limosum
- Peptostreptococcus anaerobius
- Candida albicans
Komabe, nkhani yaying'ono imaperekedwa ponena za momwe Angelica angaletsere izi ndi mabakiteriya ena ndi bowa.
Ntchito Zina
Mu mankhwala achikhalidwe,Angelica archangelicaamagwiritsidwa ntchito pochiza matenda ena, kuphatikizapo:1
Umboni wabwino wasayansi wotsimikizira kugwiritsa ntchito izi ndi wochepa. Onetsetsani kuti mulankhulane ndi wothandizira zaumoyo musanagwiritse ntchito Angelica pazinthu izi ndi zina zaumoyo.
Kodi Zotsatira Zake za Angelica Ndi Chiyani?
Mofanana ndi zitsamba zilizonse kapena zowonjezera, Angelica angayambitse zotsatira zake. Komabe, chifukwa cha kusowa kwa mayesero aumunthu, pakhala pali malipoti ochepa okhudza zotsatira za Angelica.
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Koyera zachilengedwe organic magnolia zofunika mafuta flos magnoliae mafuta mafuta onunkhira
Magnoliae Flos ndi mankhwala omwe amagwiritsidwa ntchito kwambiri ku Asia. Amagwiritsidwa ntchito pochiza sinusitis, kutsekeka kwa m'mphuno, ndi khungu la hypersensitive. Chifukwa Magonlia Flos amafotokozedwa ngati chinthu chonunkhira m'malemba akale achi China, tidaganiza kuti mafuta ake ofunikira atha kugwiritsidwa ntchito pochiza matenda a chitetezo chamthupi. Ma cell a dendritic (DCs), omwe amawonedwa ngati chandamale chachikulu cha ma immunomodulators kuti athe kuwongolera mayankho a chitetezo chamthupi, amatenga gawo lofunikira pakuyankha kwa chitetezo chamthupi. Mu phunziro ili, Magnoliae Flos mafuta ofunikira (MFEO) adachepetsa kupanga ma cytokines TNF- α, IL-6, ndi IL-12p70 mu lipopolysaccharide (LPS) -zolimbikitsa DCs. Idaponderezanso zolembera za MHC II, CD80, ndi CD86 mu LPS-stimulated DCs. Zitsanzo za zinyama zimasonyeza kuti 2,4-Dinitro-1-fluorobenzene (DNFB) yomwe imayambitsa kukhudzana ndi hypersensitivity kuyankha inali yoletsedwa kutsatira chithandizo ndi MFEO. Kuonjezera apo, MFEO inaletsa kulowetsa kwa maselo a T m'makutu a mbewa za DNFB. Kuti mufufuze mankhwala ake a bioactive, zigawo za MFEO zinawunikidwa pogwiritsa ntchito gas chromatography (GC) ndi GC-mass spectrometry. Zotsatira zinawulula kuti mankhwala akuluakulu mu MFEO ndi camphor ndi 1,8-cineole. Ma bioassays owonjezera a DC adatsimikizira kuti mankhwalawa amapondereza kwambiri kupanga ma cytokine mu ma DC opangidwa ndi LPS. Choncho, tidawonetsa kuti MFEO imasonyeza mphamvu ya immunosuppressive mu vivo ndi mu vitro, ndipo camphor ndi 1,8-cineole zikhoza kukhala zigawo zazikulu zomwe zimapangitsa kuti chitetezo cha mthupi chitetezeke. Zomwe zapezazi zikuwonetsa kuti MFEO ili ndi kuthekera kopangidwa ngati njira yatsopano yothanirana ndi matenda ochulukirapo.
