Mafuta Ofunika 100% Achilengedwe A Eucommiae Foliuml Ofunika Kwambiri Osamalira Khungu

Kufotokozera mwachidule:

Eucommia ulmoides(EU) (yomwe nthawi zambiri imatchedwa "Du Zhong" m'chinenero cha Chitchaina) ndi ya banja la Eucommiaceae, mtundu wa mtengo wawung'ono wochokera ku Central China [1]. Chomerachi chimalimidwa kwambiri ku China pamlingo waukulu chifukwa cha kufunikira kwake kwamankhwala. Pafupifupi mankhwala a 112 adasiyanitsidwa ndi EU omwe akuphatikizapo lignans, iridoids, phenolics, steroids, ndi mankhwala ena. Zowonjezera zitsamba za chomera ichi (monga tiyi wokoma) zawonetsa mankhwala ena. Tsamba la EU liri ndi zochitika zapamwamba zokhudzana ndi cortex, maluwa, ndi zipatso [2,3]. Masamba a EU akuti amathandizira kulimbitsa mafupa ndi minofu ya thupi [4], zomwe zimatsogolera ku moyo wautali komanso kulimbikitsa chonde mwa anthu [5]. Tiyi wokoma wa tiyi wopangidwa kuchokera ku tsamba la EU akuti amachepetsa kunenepa ndikuwonjezera mphamvu ya metabolism. Mafuta a Flavonoid (monga rutin, chlorogenic acid, ferulic acid, ndi caffeic acid) adanenedwa kuti akuwonetsa ntchito za antioxidant m'masamba a EU.6].

Ngakhale pakhala pali mabuku okwanira okhudzana ndi phytochemical properties ku EU, maphunziro ochepa adakhalapo okhudza pharmacological katundu wa mankhwala osiyanasiyana otengedwa ku khungwa, mbewu, zimayambira, ndi masamba a EU. Pepala lowunikirali lifotokoza mwatsatanetsatane zamitundu yosiyanasiyana yotengedwa m'magawo osiyanasiyana (makungwa, mbewu, tsinde, ndi tsamba) a EU komanso momwe angagwiritsire ntchito mankhwalawa polimbikitsa thanzi ndi maumboni asayansi ndipo potero apereka chidziwitso. kuti agwiritse ntchito EU.

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Kupereka Mphamvu:10000 Chidutswa/Zidutswa pamwezi

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Lignans ndi zotuluka zawo ndi zigawo zikuluzikulu za EU [7]. Mpaka pano, 28 lignans (monga bisepoxylignans, monoepoxylignans, neolignans, ndi sesquilignans) asiyanitsidwa ndi khungwa, masamba, ndi mbewu za EU. Iridoid glycoside, kalasi ya metabolites yachiwiri, ndi gawo lachiwiri lalikulu la EU. Iridoids imapezeka muzomera zomwe zimadziwika kuti glycosides. Ma iridoid makumi awiri ndi anayi asiyanitsidwa ndikuzindikiridwa ku EU (Table 1). Mankhwala odzipatula awa ndi monga geniposidic acid, aucubin, ndi asperuloside omwe akuti ali ndi mphamvu zambiri zamankhwala [8-10]. Mitundu iwiri yatsopano ya iridoids, Eucommides-A ndi -C, yapatulidwa posachedwa. Mitundu iwiri yachilengedweyi imatengedwa ngati ma conjugates a iridoid ndi amino acid. Komabe, makina omwe amathandizira ntchito yawo palibe [11].

2.2. Phenolic Compounds

Mankhwala a phenolic omwe amachokera ku zakudya zanenedwa kuti ali ndi zotsatira zabwino pa thanzi laumunthu [12,13]. Pafupifupi 29 mankhwala a phenolic adasiyanitsidwa ndikuzindikiridwa kuchokera ku EU [14]. Zonse zomwe zili mu mankhwala a phenolic (mu gallic acid ofanana ndi zowonjezera zonse) adawunikidwa pogwiritsa ntchito Folin-Ciocalteu phenol reagent. Zotsatira za kusintha kwa nyengo pazomwe zili muzinthu zina ndi ma antioxidants zanenedwa. M'chaka chomwecho, zomwe zili pamwamba pa phenolics ndi flavonoids zinapezeka m'masamba a EU mu August ndi May, motsatira. Rutin, quercetin, geniposidic acid, ndi aucubin analipo kwambiri mu Meyi kapena June.15]. Kuphatikiza apo, ntchito zapamwamba za 1,1-diphenyl-2-picrylhydrazyl (DPPH) zowononga kwambiri komanso luso lachitsulo la ion chelating zidapezeka m'masamba a EU omwe adakololedwa mu Ogasiti. Kuchulukitsitsa kwazakudya za antioxidants kudanenedwanso mu Meyi poyerekeza ndi nthawi zina pachaka [15]. Tsamba la EU lapezeka kuti lili ndi ma amino acid, mavitamini, mchere, ndi flavonoids monga quercetin, rutin, ndi geniposidic acid.11,16]. Okwana 7 flavonoids akhala olekanitsidwaEucommiazomera [17]. Rutin ndi quercetin ndi flavonoids zofunika kwambiri.18]. Flavonoids ndi mankhwala ofunikira omwe amapezeka mwachilengedwe ndipo amawonedwa ngati ma metabolites achiwiri ndipo amagwira ntchito ngati ma messenger amankhwala, owongolera thupi, ndi zoletsa ma cell cycle.

2.3. Steroids ndi Terpenoids

Ma steroid asanu ndi limodzi ndi ma terpenoids asanu achotsedwa ndikugawidwa ku EU. Izi zikuphatikizapoβ-sitosterol, daucosterol, ulmoprenol, betalin, betulic acid, ursolic acid, eucommidiol, rehmaglutin C, ndi 1,4α,5, 7α-tetrahydro-7-hydroxymethyl-cyclopenta[c]pyran-4-carboxylic methyl ester yomwe inali yotalikirana ndi khungwa la EU [19]. Loliolide yasiyanitsidwanso ndi masamba [20].

2.4. Polysaccharides

Ma polysaccharides ochokera ku EU kwa masiku a 15 pamlingo wa 300-600 mg/kg adanenedwa kuti akuwonetsa chitetezo pa impso monga momwe malonaldehyde ndi glutathione amachitira pambuyo potulutsa aimpso [21]. Kufufuza kwa histological kunawonetsanso umboni wa antioxidative properties. Zotulutsa kuchokera ku khungwa la EU pogwiritsa ntchito 70% ethanol zidawonetsanso zoteteza ku cadmium pa 125-500 mg/kg.22]. Histological kufufuza anasonyezanso kuti EU osakaniza ndiPanax pseudoginsengpa 25% ndi 50% kulemera, motero, kwa masabata asanu ndi limodzi pa mlingo wa 35.7-41.6 mg / kg anawonetsa kuwala koteteza pa mlingo wa kusefera kwa glomerular [8]. Ma polysaccharides awiri atsopano asiyanitsidwa ndi EU, omwe ndi eucomman A ndi B [23].

2.5. Zina Zosakaniza ndi Mankhwala

Ma amino acid, ma microelements, mavitamini, ndi mafuta acids adasiyanitsidwanso ndi EU.17,21-23]. Sun et al. adapezanso mankhwala atsopano monga n-octacosanoic acid, ndi tetracosanoic-2,3-dihydroxypropylester ochokera ku EU [24].

Mafuta amtundu wa mafuta opangidwa kuchokera ku mbewu ya EU adawonetsa mitundu yosiyanasiyana yamafuta a polyunsaturated acids monga linoleic acid, linolenic acid (56.51% yamafuta onse amafuta, TFAs), ndi linolelaidic acid (12.66% ya TFAs). Pakadali pano, mafuta amtundu wa monounsaturated otalikirana ndi mbewu adapezeka kuti ndi isoleic acid (15.80% ya TFAs). Mafuta ambiri odzaza mafuta omwe ali olekanitsidwa ndi palmitic acid ndi stearic acid omwe amayimira 9.82% ndi 2.59% ya TFAs, motsatana.